Autoimmune diabetes (LADA)
Latent Autoimmune Diabetes in Adults (LADA) is a slower-onset form of autoimmune diabetes that develops in adulthood, and is sometimes mistaken for type 2 diabetes at first because of its gradual progression.
Symptoms
- Symptoms similar to type 2 diabetes initially — increased thirst, fatigue, frequent urination
- Gradual worsening of blood glucose control despite oral medication
- Often diagnosed in adults who don't fit the typical type 2 profile (e.g. lower body weight)
Causes & risk factors
- An autoimmune process similar to type 1 diabetes, but progressing more slowly
- A personal or family history of autoimmune conditions
How it’s diagnosed
LADA is suspected when an adult diagnosed with apparent type 2 diabetes doesn't respond as expected to oral medication; antibody testing (similar to type 1 diabetes) can confirm an autoimmune basis.
How it’s treated
Management typically shifts toward insulin earlier than in typical type 2 diabetes, since beta-cell function tends to decline faster. Treatment is individualized based on antibody status and how the condition is progressing.
When to seek care
- Blood glucose control worsening despite oral medication
- Unintended weight loss alongside high blood glucose
- Symptoms of very high or very low blood glucose
FAQ
How is LADA different from type 1 and type 2 diabetes?
LADA is autoimmune like type 1 diabetes, but progresses more slowly, so it's often diagnosed in adulthood and initially resembles type 2 diabetes.
Sources
- American Diabetes Association, Standards of Care in Diabetes—2026
Medical disclaimer: Content on this page is for general education and is not a substitute for individualized medical advice, diagnosis, or treatment. Outcomes vary between patients. Boston Diabetes Center is outpatient / day-care specialty centre with an on-site diagnostic lab and pharmacy — no inpatient beds; imaging and inpatient care are coordinated through partner facilities.