ISR (Insulin Sensitivity Restoration)
ISR (Insulin Sensitivity Restoration) is an adjunctive therapy used alongside standard-of-care diabetes management, aimed at insulin resistance and its downstream effects.
Who it’s for
Patients with uncontrolled blood sugar, insulin resistance, or microvascular complications (such as neuropathy, kidney disease, or foot ulcers) being managed alongside — not instead of — standard-of-care treatment.
What to expect
The practice offers ISR pulsatile insulin therapy as an addition to your existing management plan; your care team will discuss whether it's an appropriate adjunct given your specific diagnosis and current treatment.
Evidence basis
ISR's scientific basis is grounded in the physiologic insulin resensitization literature (PMC8836751 / PMID 35163806), a peer-reviewed review evaluating this approach for insulin-resistance pathophysiology. It is presented here strictly as an adjunctive therapy alongside standard-of-care management — never as a replacement for it, and without any outcome guarantee.
Sources
- Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology, PMC8836751 (PMID 35163806)
Medical disclaimer: Content on this page is for general education and is not a substitute for individualized medical advice, diagnosis, or treatment. Outcomes vary between patients. Boston Diabetes Center is outpatient / day-care specialty centre with an on-site diagnostic lab and pharmacy — no inpatient beds; imaging and inpatient care are coordinated through partner facilities.